Rheumatoid arthritis
RA; Arthritis - rheumatoid
Last reviewed: February 7, 2010.
National Center for Biotechnology Information
U.S. National Library of Medicine
National Institutes of Health
Rheumatoid arthritis (RA) is a long-term disease that leads to inflammation of the joints and surrounding tissues. It can also affect other organs.
Causes, incidence, and risk factors
The cause of RA is unknown. It is considered an autoimmune disease. The body's immune system normally fights off foreign substances, like viruses. But in an autoimmune disease, the immune system confuses healthy tissue for foreign substances. As a result, the body attacks itself.
RA can occur at any age. Women are affected more often than men.
RA usually affects joints on both sides of the body equally. Wrists, fingers, knees, feet, and ankles are the most commonly affected. The course and the severity of the illness can vary considerably. Infection, genes, and hormones may contribute to the disease.
Symptoms
The disease often begins slowly, with symptoms that are seen in many other illnesses:
- Fatigue
- Low fever
- Swollen glands
- Weakness
Eventually, joint pain appears.
- Morning stiffness, which lasts more than 1 hour, is common. Joints can even become warm, tender, and stiff when not used for as little as an hour.
- Joint pain is often felt on both sides of the body.
- The fingers (but not the fingertips), wrists, elbows, shoulders, hips, knees, ankles, toes, jaw, and neck may be affected.
- The joints are often swollen and feel warm and boggy (or spongy) to the touch.
- Over time, joints lose their range of motion and may become deformed.
Other symptoms include:
- Chest pain when taking a breath (pleurisy)
- Nodules under the skin (usually a sign of more severe disease)
- Numbness, tingling, or burning in the hands and feet
Joint destruction may occur within 1 - 2 years after the disease appears.
